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Correlation between IL-17 and inflammatory bowel disease
Hiba T Majeed1, Zahraa Y Motaweq2
1Department of Vision Screening Techniques, College of Health and Medical Techniques, Al-Forat Al-Awsat University Kufa, Iraq.
The Egyptian Journal of Immunology
|January 13, 2025
Summary
Elevated serum Interleukin-17 (IL-17) levels are linked to inflammatory bowel disease (IBD) activity. Monitoring IL-17 may help assess IBD severity and guide treatment for Crohn's disease and ulcerative colitis.
Area of Science:
- Gastroenterology and Immunology
- Biomarker Discovery
- Chronic Disease Pathophysiology
Background:
- Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, involves chronic gastrointestinal inflammation driven by immune dysregulation.
- Interleukin-17 (IL-17) is implicated in IBD pathogenesis, with IL-17 inhibitors sometimes associated with IBD onset or exacerbation.
Purpose of the Study:
- To investigate the association between serum IL-17 levels and disease activity in patients with IBD.
- To evaluate IL-17 as a potential biomarker for IBD severity and treatment guidance.
Main Methods:
- A case-control study involving 102 IBD patients and 48 healthy controls.
- Serum IL-17 levels were quantified using the enzyme-linked immunosorbent assay (ELISA).
Main Results:
- Patients with IBD exhibited significantly higher serum IL-17 levels compared to the control group (p=0.0001).
- Elevated IL-17 levels were observed across various age groups (1-15, 16-30, and 31-45 years).
- IL-17 levels were higher in Crohn's disease than in ulcerative colitis (p=0.001) and showed significant differences between sexes (p=0.0001).
Conclusions:
- Higher serum IL-17 levels in IBD patients suggest a role for this cytokine in the development and pathophysiology of Crohn's disease and ulcerative colitis.
- Serum IL-17 may serve as a valuable biomarker for assessing IBD severity and informing therapeutic strategies.
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