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Updated: Jun 2, 2025

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor SiFA for Positron Emission Tomography
Published on: January 11, 2020
Radiolabeling of Siamenoside I with Carbon-14
Goran Petrović1, Jonathan Bristow2, Steven F Sukits1
1The Coca-Cola Company, One Coca-Cola Plaza, Atlanta, Georgia 30313, United States.
None:
The synthesis of radiolabeled [25-14C]-siamenoside I following a synthetic route developed using unlabeled materials is disclosed. The synthesis features an early stage labeling of the mogrol's C25 via an oxidative cleavage-reconstruction strategy and regioselective glycosylations directed by protecting group manipulations. This route provided access to adequate amounts of [25-14C]-siamenoside I for in vivo ADME and PK studies.
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