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Synthetic Strategy for Unsymmetrical α-Fluoro-α'-aryl Ketones
Shubham Dutta1, Avijit Maity1, Shengwen Yang2
1School of Chemistry, University of Hyderabad, Hyderabad 500046, India.
Abstract:
α-Fluoro-α'-aryl ketones are crucial in pharmaceuticals and agrochemicals. However, synthesizing unsymmetrical α-fluoro-α'-aryl ketones poses regioselective challenges. This study presents a one-pot aryl-oxy-fluorination method for synthesizing such unsymmetrical fluoro-aryl ketones. Using ynamide, aryl boronic acid, and F-source under Pd-catalysis, this method efficiently produces a wide range of valuable α-fluoro-α'-aryl ketones with potential applications. Through a combination of control experiments and DFT studies, we proposed a reaction mechanism involving in situ acetic acid formation.
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