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In Situ Self-Assembled Naringin/ZIF-8 Nanoparticle-Embedded Bacterial Cellulose Sponges for Infected Diabetic Wound
Zhao Wei1, Mark Robertson2, Jin Qian2
1Institute of Nano and Biopolymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China.
ACS Applied Materials & Interfaces
|January 13, 2025
Summary
A new multifunctional sponge, combining zeolitic imidazolate framework-8/bacterial cellulose (ZIF-8/BC) with naringin, effectively treats diabetic foot ulcers (DFUs). This advanced dressing promotes wound healing by managing exudate, fighting infection, and enhancing blood vessel growth.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing
Background:
- Diabetic foot ulcers (DFUs) present a significant clinical challenge due to complex wound microenvironments.
- Infection, inflammation, and impaired angiogenesis impede healing and reduce treatment efficacy.
- Novel strategies are needed to effectively manage DFUs and promote tissue regeneration.
Purpose of the Study:
- To develop a multifunctional sponge dressing for enhanced diabetic foot ulcer healing.
- To incorporate zeolitic imidazolate framework-8 (ZIF-8) and naringin (Nar) into a bacterial cellulose (BC) matrix.
- To evaluate the physicochemical, antimicrobial, and in vivo therapeutic properties of the Nar/ZIF-8/BC sponge.
Main Methods:
- Fabrication of the Nar/ZIF-8/BC sponge via in situ synthesis and lyophilization.
- Assessment of mechanical properties, water absorption, and antimicrobial activity.
- In vivo study using a diabetic rat model to evaluate wound healing efficacy.
Main Results:
- The Nar/ZIF-8/BC sponge demonstrated excellent mechanical strength (2.28 MPa) and high water absorption (~70x).
- Achieved 100% antimicrobial activity and exhibited pH-responsive naringin release.
- Promoted angiogenesis, antioxidant, and anti-inflammatory effects, accelerating infected DFU healing in rats.
Conclusions:
- The Nar/ZIF-8/BC sponge is a promising multifunctional dressing for DFU treatment.
- The dressing effectively regulates the wound microenvironment, addressing key challenges in DFU healing.
- This approach offers an efficient solution for managing complex and intractable wounds.
