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Serum Nutrients, Periodontitis and Biological Ageing.

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Certain blood nutrients like vitamin E and cis-β-carotene are linked to longer telomeres and may impact aging. These nutrient-telomere associations, along with periodontitis risk, can be influenced by factors like sex and race.

Keywords:
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Area of Science:

  • Nutritional science
  • Genetics
  • Periodontology

Background:

  • Telomere shortening is linked to aging, oxidative stress, and periodontitis.
  • Dietary nutrients play a role in chronic inflammatory diseases like periodontitis.
  • Investigating nutrient associations with telomere length and periodontitis is crucial for understanding biological aging.

Purpose of the Study:

  • To test the hypothesis that blood serum levels of specific vitamins (folate, D, E, cis-β-carotene, β-cryptoxanthin) are associated with telomere lengths and periodontitis.
  • To determine if demographic factors (age, sex, smoking, race/ethnicity) modify these relationships.

Main Methods:

  • Analysis of laboratory and demographic data from 10,793 participants in the NHANES 1999-2002 survey.
  • Assessment of periodontitis status, vitamin levels, telomere lengths, and smoking habits.
  • Statistical analysis using ANOVA tests to identify significant associations and interactions.

Main Results:

  • Periodontitis showed significant associations with vitamin D, vitamin E, and cis-β-carotene.
  • Telomere length was significantly associated with vitamin E and cis-β-carotene.
  • Significant interactions were found between folate and sex, vitamin D and periodontitis, vitamin D and race/ethnicity, and vitamin E and sex concerning telomere length.

Conclusions:

  • Specific blood nutrients may influence biological aging processes, with periodontitis as a potential co-morbidity.
  • Demographic variables such as sex and race/ethnicity can modify the relationships between nutrients, telomere length, and periodontitis.