Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.1K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises...
1.1K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.3K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.3K
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

2.1K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
2.1K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

863
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
863
Neurotransmitters01:31

Neurotransmitters

803
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
803
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

9.7K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
9.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Astrocytic ankyrin-2 enables memory persistence in the mouse hippocampus.

Nature communications·2026
Same author

Incidence Patterns and Prognostic Impact of Lung-Involving Multiple Primary Cancers: A 10-Year Hospital-Based Cohort Study.

Thoracic cancer·2026
Same author

Sustainable and green novel sorbent-based immobilization of PFAS and their enhanced adsorption to treat environmental contamination.

Critical reviews in biotechnology·2026
Same author

Efficacy and Safety of <i>Bacillus coagulans</i> IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study.

Nutrients·2026
Same author

Noninvasive Detection of Acute Hyperglycemia Using Signal from Wearable ECG Sensors Considering Individual HRV Response Delays to Glucose.

Biosensors·2026
Same author

Dynamics of dislocation formations and their impacts on exsolution in Ru-doped perovskite oxide.

Nature communications·2026

Related Experiment Video

Updated: Jun 2, 2025

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.3K

Neurosteroids and neurological disorders.

Gi Wan Park1, Hayoung Kim1, Seong Hyun Won1

  • 1Department of Medicine, Catholic Kwandong University College of Medicine, Gangneung 25601, Korea.

The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
|January 14, 2025
PubMed
Summary

Neurosteroids, locally produced in the brain, modulate neuronal excitability and glial cell activity. Their altered levels are linked to neurological disorders, suggesting therapeutic potential.

Keywords:
GABAN-methyl-D-aspartateNervous system diseasesNeurosteroidsReceptorsSigma-1 receptor

More Related Videos

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
10:08

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

2.1K
Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
09:24

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

17.7K

Related Experiment Videos

Last Updated: Jun 2, 2025

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.3K
Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
10:08

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

2.1K
Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE
09:24

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

17.7K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Cell Biology

Background:

  • Neurosteroids are endogenous neuromodulators synthesized within the central nervous system (CNS).
  • They rapidly influence neuronal excitability and glial cell (microglia, astrocytes) activation.
  • Neurosteroids interact with various CNS receptors, including GABA-A, NMDA, calcium channels, and sigma-1 receptors.

Purpose of the Study:

  • To review the synthesis, metabolism, and actions of neurosteroids in the CNS.
  • To explore the role of neurosteroids in physiological and pathological conditions.
  • To discuss the therapeutic potential of neurosteroids for neurological disorders.

Main Methods:

  • Literature review of neurosteroid synthesis, metabolism, and function.
  • Analysis of neurosteroid involvement in neurological disorders.
  • Discussion of therapeutic applications.

Main Results:

  • Neurosteroids modulate neuronal and glial activity through specific receptor interactions.
  • Altered neurosteroid levels are observed in conditions like neuropathic pain, multiple sclerosis, and seizures.
  • Local synthesis and metabolism of neurosteroids are dynamically regulated in the CNS.

Conclusions:

  • Neurosteroids are critical CNS modulators with diverse physiological roles.
  • Dysregulation of neurosteroids is implicated in various neurological diseases.
  • Neurosteroids represent a promising therapeutic avenue for treating neurological disorders.