Altered Cytokine Production in Patients with Helicobacter pylori Infection
Abdollah Safikhani Mahmoodzadeh1, Elham Moazamian1, Seyedeh Azra Shamsdin2
1Department of Microbiology, College of Sciences, Agriculture and Modern Technology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
Helicobacter pylori infection elevates specific inflammatory cytokines, including IL-17A, IL-17F, and IL-22, which are linked to moderate gastritis development in patients.
Area of Science:
- Gastroenterology
- Immunology
- Microbiology
Background:
- Helicobacter pylori is a gram-negative pathogen associated with gastritis and increased gastric cancer risk.
- This study examines the link between H. pylori infection, gastritis, and serum inflammatory cytokine profiles.
Purpose of the Study:
- To investigate the relationship between H. pylori infection and changes in serum inflammatory cytokine levels.
- To determine the role of specific cytokines in the development of gastritis.
Main Methods:
- Blood samples collected from 85 patients (46 H. pylori-positive, 39 H. pylori-negative).
- H. pylori isolation and identification, followed by histopathological assessment of gastritis severity.
- Serum cytokine levels measured using multiplex kits and flow cytometry.
Main Results:
- Significant differences in IL-2, IL-4, IL-17A, IL-17F, IL-22, TNF-α, and IFN-γ levels between H. pylori-positive and negative groups.
- Elevated levels of IL-2, IL-17A, IL-17F, IL-22, TNF-α, and IFN-γ in patients with mild/moderate gastritis compared to H. pylori-negative individuals.
- Increased IL-4 levels observed in patients with moderate gastritis.
Conclusions:
- IL-17A, IL-17F, and IL-22 may play a significant role in the pathogenesis of moderate gastritis in H. pylori-infected patients.
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