Related Experiment Video
Updated: Jun 14, 2025
In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
Published on: June 8, 2022
Ileo-ileal intussusception and necrotising enterocolitis after indomethacin exposure masquerading clinically as
Irene Wen Hui Tu1, Esther Ern Hwei Chan2, Narasimhan Kannan Laksmi1
1Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore.
Abstract:
We report a case of small bowel perforation from ileo-ileal intussusception with necrotising enterocolitis (NEC) after indomethacin exposure mimicking spontaneous intestinal perforation in an extremely preterm neonate. Indomethacin exposure can cause mesenteric hypoperfusion, resulting in an ischaemic lead point for intussusception and NEC. We advocate that intussusception should be considered as one of the differentials for neonates with recurrent feeding intolerance postindomethacin exposure. Diagnosis with early ultrasound by an experienced sonographer is crucial for timely surgical reduction to prevent intestinal perforation.
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