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Patient reported tools for assessing potential medicine-related symptoms: A systematic review
Abebe Basazn Mekuria1, Henok Getachew Tegegn2, Andre Q Andrade1
1Quality Use of Medicines and Pharmacy Research Centre, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, 5001, Australia.
Background:
Medicine-related symptom assessment tools have been developed to assist healthcare professionals in detecting potential medicine-related symptoms. This systematic review aimed to identify and evaluate the measurement properties of medicine-related symptom assessment tools.
Method:
A systematic search was conducted in Ovid Medline, Ovid Embase, Ovid PsychInfo, and SCOPUS databases up to March 16, 2024. The primary studies that described either the development or measurement properties of a tool for identifying medicine-related symptoms were included. Screening and data extraction was done independently by two reviewers using Covidence. The methodological risk of bias and assessment results of reported measurement properties were evaluated using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist.
Result:
Eleven studies met the inclusion criteria, reporting on nine unique tools. All included tools had sufficient content validity assessment results. The PHArmacotherapeutical Symptom Evaluation-20 (PHASE-20) had adequate to very good methodological quality internal consistency, construct validity, and reliability. The Patient-Reported Adverse Drug Event Questionnaire also showed adequate methodological quality with sufficient reliability, criterion validity, and construct validity but required over 30 min to complete. The PHASE-proxy exhibited adequate to very good methodological quality, with sufficient results in criterion validity, structural validity, internal consistency, and reliability. The Patient-Reported Outcome Measure Inquiry into Side-Effects showed sufficient content validity but lacked data on other measurement properties.
Conclusion:
The majority of the identified tools were tested for one or more measurement properties. Among these tools, PHASE-20 is suitable for assessing medicine-related symptoms in elderly individuals who can participate independently, while PHASE-Proxy is for older adults with dementia or communication disabilities in nursing homes.
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