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Methods to Study Lipid Alterations in Neutrophils and the Subsequent Formation of Neutrophil Extracellular Traps
Published on: March 29, 2017
The association between neutrophil to high-density lipoprotein cholesterol ratio and gallstones: a cross-sectional
Yinkang Wang1,2, Xingchen Shang1,2, Yinchao Zhang1,2
1Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Insights
The neutrophil to high-density lipoprotein cholesterol ratio (NHR) shows a near-linear association with an increased risk of gallstones in American adults. While NHR has some predictive value, its power is weak compared to other markers.
Area of Science:
- Biochemistry
- Epidemiology
- Clinical Medicine
Background:
- Cholesterol's link to gallstones is well-established.
- High-density lipoprotein cholesterol (HDL-C) is a key lipid marker.
- The neutrophil to HDL-C ratio (NHR) is an emerging biomarker.
Purpose of the Study:
- To investigate the association between NHR and gallstone prevalence in US adults.
- To evaluate the predictive capability of NHR for gallstone risk.
Main Methods:
- Utilized 2017-2020 National Health and Nutrition Examination Survey (NHANES) data.
- Calculated NHR by dividing neutrophil count by HDL-C.
- Employed logistic regression, restricted cubic splines, and ROC curve analysis.
Main Results:
- A significant positive association was found between NHR and gallstones (OR=1.05, 95% CI: 1.01-1.10).
- The relationship between NHR and gallstones was determined to be near-linear.
- The ROC analysis indicated NHR has a predictive value (AUC=0.550) for gallstone development.
Conclusions:
- NHR is associated with increased gallstone susceptibility in a near-linear fashion.
- NHR demonstrates weak but present predictive value for gallstone risk.
- Further prospective studies are required to validate NHR's role in gallstone pathogenesis.
Objective:
Several studies have discussed the relationship between cholesterol and gallstones, and high-density lipoprotein cholesterol (HDL-C) as a representative of this has been addressed in various diseases. The metric neutrophil to high-density lipoprotein cholesterol ratio (NHR) derived from HDL-C has attracted much attention. The purpose of this article is to examine the relationship between NHR and gallstones in a population of American adults.
Methods:
This study investigated the correlation between NHR and gallstone prevalence among US adults using population-based data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). NHR was derived by dividing the neutrophil count by HDL-C. Data were analyzed using a variety of statistical techniques, such as univariate analysis, multivariate analysis, and subgroup analysis. In addition, a receiver operating characteristic curve (ROC) was used to determine the predictive power of the index for the risk of gallstone prevalence.
Results:
The trial enrolled 6,954 subjects, among whom 746 patients were diagnosed with gallstones. By fully adjusted multivariate logistic regression analysis in the Model 3 section observed a significant positive association between NHR and gallstones with an odds ratio (OR) of 1.05 and a 95% confidence interval (CI) of (1.01, 1.10). The restricted cubic curve (RCS) had a P-Nonlinear = 0.481, suggesting that the relationship was a near-linear one. The area under the curve (AUC) of the ROC curve was 0.550, indicating that NHR has a predictive value for the development of gallstones.
Conclusion:
This study demonstrated a near-linear correlation between NHR and increased susceptibility to gallstones, and the ROC curve is evidence that NHR has some predictive value for the risk of gallstones, albeit with weak predictive power relative to NPAR (Neutrophil percentage/albumin) and NAR (Neutrophils/albumin). Of course, to confirm these findings, more extensive prospective studies are needed to thoroughly validate the role of NHR in the development of gallstones.
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