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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

620
In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
620
Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

502
Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
The ions and electrons produced interact with the fluctuating magnetic field created by a water-cooled...
502
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

377
Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
377
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

554
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
554
Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

186
Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy  (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
186

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Related Experiment Video

Updated: Jun 2, 2025

A Microfluidic Chip for ICPMS Sample Introduction
11:16

A Microfluidic Chip for ICPMS Sample Introduction

Published on: March 5, 2015

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Particle Trajectory Simulation Facilitates the Development of an Efficient Sample Introduction System for

Dingyi Wang1, Junhui Zhang1,2, Changjun Fan3

  • 1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Analytical Chemistry
|January 15, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces a novel sample introduction system for Inductively Coupled Plasma Mass Spectrometry (ICP-MS) single-event analysis. It achieves high particle transport efficiency through computational design and 3D printing, improving accuracy for analyzing single cells and particles.

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Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
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Last Updated: Jun 2, 2025

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A Practical Guide on Coupling a Scanning Mobility Sizer and Inductively Coupled Plasma Mass Spectrometer SMPS-ICPMS
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Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Materials Science

Background:

  • Inductively coupled plasma mass spectrometry (ICP-MS) is crucial for single-event analysis (e.g., single cells, particles).
  • Enhancing sample introduction system efficiency is vital for accurate single-event ICP-MS analysis.
  • Previous research often relied on empirical methods, lacking theoretical particle characterization and efficient manufacturing for optimization.

Purpose of the Study:

  • To develop a high-efficiency sample introduction system for single-event ICP-MS analysis.
  • To integrate computational simulation, 3D printing, and experimental testing for system optimization.
  • To provide theoretical guidance for designing and optimizing ICP-MS components.

Main Methods:

  • Computational simulation of particle trajectories within the spray chamber.
  • Precise 3D printing of the spray chamber using various materials.
  • In-house fabrication and rapid experimental testing of the system.
  • Optimization of operating parameters, such as temperature.

Main Results:

  • Simulated particle trajectories provided theoretical insights into transport efficiency.
  • Particles between 20-100 nm achieved >18.8% transport efficiency under absorption boundary conditions.
  • Particles >100 nm showed 0% transport efficiency due to deposition.
  • Optimized system achieved a transport efficiency of 61.1%.

Conclusions:

  • The integrated workflow of simulation-aided design, 3D printing, and testing significantly enhances ICP-MS sample introduction systems.
  • This approach offers a cost-effective and efficient method for developing and validating critical mass spectrometry components.
  • The developed system demonstrates potential for transforming future research and development in mass spectrometry.