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Updated: Jun 2, 2025

Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
The Importance of Cellular Therapy in the Clinical Case of a Young Man With a Challenging Precursor B-cell
Catarina F Almeida1, Liliana Fonseca2, Inês Ramos3
1Immunohemotherapy Department, Unidade de Saúde Local da Região de Aveiro, Aveiro, PRT.
Abstract:
Acute lymphoblastic leukemia (ALL) poses a significant challenge due to its high relapse rate despite initial chemotherapy. Cell therapy plays an important and promising role in refractory ALL cases. The aim is to present a complex case of a 20-year-old male patient with relapsed ALL and to explore the different therapeutic options of cellular therapy - allogeneic hematopoietic stem cell transplantation, donor lymphocyte infusion, and chimeric antigen receptor T - detailing the collection, processing, and infusion, as well as the associated complications and management strategies. Data were collected from patient records. This case highlights the evolving landscape of immunotherapy in hematological malignancies and emphasizes the importance of optimizing cellular therapy approaches for improved patient outcomes.
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