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Success Rates of Assisted Reproduction for Men With Cystic Fibrosis.
Karuna Sapru1,2, Joanna Wilkinson1,2, Anthony K Webb1,2
1Department of Respiratory Medicine, Manchester Adult Cystic Fibrosis Centre, North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK.
Pediatric Pulmonology
|January 15, 2025
Summary
Assisted reproductive technology enables most men with cystic fibrosis (CF) and azoospermia to achieve live births. Fertility treatment success rates are high, but clinical status impacts prognosis for men with CF.
Area of Science:
- Reproductive Medicine
- Cystic Fibrosis Research
- Andrology
Background:
- Cystic Fibrosis (CF) predominantly causes infertility in men.
- Advances in assisted reproductive technology (ART) offer a pathway to biological fatherhood for these individuals.
Purpose of the Study:
- To evaluate the success rates of fertility treatments in men with CF.
- To assess the impact of clinical status on fertility treatment outcomes in men with CF.
Main Methods:
- Retrospective analysis of 71 men with CF and azoospermia over 23 years.
- Evaluation of surgical sperm retrieval (SSR), intracytoplasmic sperm injection (ICSI), and live birth rates.
- Correlation of clinical parameters (FEV1, BMI) with treatment success and survival.
Main Results:
- Successful SSR was achieved in 98.5% of men.
- Intracytoplasmic sperm injection (ICSI) led to live births in 84% of initiated cycles.
- Higher FEV1 and BMI were associated with improved survival rates post-treatment.
Conclusions:
- Fertility treatment is successful in over 75% of men with CF undergoing ART.
- Prognosis and clinical status are critical considerations for fertility service referrals in men with CF.
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