Related Experiment Video

Updated: Jul 9, 2026

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations
04:46

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Published on: February 24, 2023

1.4K

Emerging nanoplatforms towards microenvironment-responsive glioma therapy

Nigam Sekhar Tripathy1, Liza Sahoo1, Safal Paikray1

  • 1School of Biotechnology, Centurion University of Technology and Management, Jatni, Bhubaneswar, Odisha, 752050, India.

Medical Oncology (Northwood, London, England)
|January 15, 2025
PubMed

Insights

Nanotechnology offers new ways to diagnose and treat aggressive brain tumors called gliomas. Multifunctional nanoplatforms show promise for improving patient survival and clinical outcomes in glioma treatment.

Area of Science:

  • Neuro-oncology
  • Nanomedicine
  • Biotechnology

Background:

  • Gliomas are aggressive central nervous system tumors with poor prognosis and high recurrence rates.
  • Accurate imaging and grading of gliomas are challenging due to tumor heterogeneity and the blood-brain barrier.
  • Traditional therapies like radiation, surgery, and chemotherapy have limitations in treating gliomas effectively.

Purpose of the Study:

  • To review recent advancements in multifunctional nanoplatforms for glioma diagnosis and treatment.
  • To highlight the potential of nanotechnology in overcoming challenges associated with glioma management.
  • To discuss novel nanotherapeutic approaches for improved patient outcomes.

Main Methods:

  • Review of recent scientific literature on nanotechnology applications in glioma research.
  • Analysis of multifunctional nanoplatforms for diagnostic and therapeutic purposes.
  • Focus on nanoplatforms for sonodynamic, photodynamic, and photothermal therapies.

Main Results:

  • Nanotechnology provides innovative strategies for glioma diagnosis and treatment.
  • Microenvironment-responsive nanoplatforms enhance therapeutic efficacy.
  • Novel nanotherapeutic platforms show potential for improved patient survival and clinical control.

Conclusions:

  • Multifunctional nanoplatforms represent a promising frontier in glioma management.
  • Nanotechnology-based therapies offer new avenues for overcoming treatment challenges.
  • Further development of nanoplatforms is crucial for advancing glioma care and patient outcomes.
Keywords:
GliomaPhotodynamic therapyPhotothermal therapyReactive oxygen speciesSonodynamic therapyTumor microenvironment

More Related Videos

Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment07:25

Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment

Published on: March 1, 2024

2.2K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.4K

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...