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Emerging nanoplatforms towards microenvironment-responsive glioma therapy
Nigam Sekhar Tripathy1, Liza Sahoo1, Safal Paikray1
1School of Biotechnology, Centurion University of Technology and Management, Jatni, Bhubaneswar, Odisha, 752050, India.
Medical Oncology (Northwood, London, England)
|January 15, 2025
Summary
Nanotechnology offers new ways to diagnose and treat aggressive brain tumors called gliomas. Multifunctional nanoplatforms show promise for improving patient survival and clinical outcomes in glioma treatment.
Area of Science:
- Neuro-oncology
- Nanomedicine
- Biotechnology
Background:
- Gliomas are aggressive central nervous system tumors with poor prognosis and high recurrence rates.
- Accurate imaging and grading of gliomas are challenging due to tumor heterogeneity and the blood-brain barrier.
- Traditional therapies like radiation, surgery, and chemotherapy have limitations in treating gliomas effectively.
Purpose of the Study:
- To review recent advancements in multifunctional nanoplatforms for glioma diagnosis and treatment.
- To highlight the potential of nanotechnology in overcoming challenges associated with glioma management.
- To discuss novel nanotherapeutic approaches for improved patient outcomes.
Main Methods:
- Review of recent scientific literature on nanotechnology applications in glioma research.
- Analysis of multifunctional nanoplatforms for diagnostic and therapeutic purposes.
- Focus on nanoplatforms for sonodynamic, photodynamic, and photothermal therapies.
Main Results:
- Nanotechnology provides innovative strategies for glioma diagnosis and treatment.
- Microenvironment-responsive nanoplatforms enhance therapeutic efficacy.
- Novel nanotherapeutic platforms show potential for improved patient survival and clinical control.
Conclusions:
- Multifunctional nanoplatforms represent a promising frontier in glioma management.
- Nanotechnology-based therapies offer new avenues for overcoming treatment challenges.
- Further development of nanoplatforms is crucial for advancing glioma care and patient outcomes.
Keywords:
GliomaPhotodynamic therapyPhotothermal therapyReactive oxygen speciesSonodynamic therapyTumor microenvironmentMore Related Videos
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