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Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
A COMBINATION REGIMEN OF INTRAVITREAL CLINDAMYCIN WITH DEXAMETHASONE, SYSTEMIC CO-TRIMOXAZOLE AND STEROIDS FOR
Sushree Satavasia1, Akshay Mishra1, Vishal Jadhav1
1L V Prasad Eye Institute, Bhubaneswar, Odisha, India.
Intravitreal clindamycin and dexamethasone injections, combined with oral medications, effectively treated ocular toxoplasmosis. This adjuvant therapy led to complete resolution of retinitis and improved vision in all patients.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Retinal Imaging
Background:
- Ocular toxoplasmosis is a significant cause of retinitis.
- Optimal treatment strategies for Toxoplasma retinochoroiditis are continually being investigated.
Purpose of the Study:
- To evaluate the efficacy of intravitreal clindamycin with dexamethasone as an adjuvant therapy.
- To assess the role of this combination in treating macular Toxoplasma retinochoroiditis alongside systemic co-trimoxazole and steroids.
Main Methods:
- A retrospective study included 39 immunocompetent patients with Toxoplasma retinochoroiditis.
- Patients received a combination of oral and intravitreal therapies.
- Data were collected from January 2014 to December 2021.
Main Results:
- All 39 patients achieved resolution of retinitis.
- A mean improvement of five lines in visual acuity was observed.
- The treatment involved an average of 1.79 intravitreal injections per patient.
Conclusions:
- Intravitreal clindamycin with dexamethasone is an effective adjuvant therapy for Toxoplasma retinochoroiditis.
- This combined approach leads to complete resolution and visual improvement.
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