Feature selectivity of corticocortical feedback along the primate dorsal visual pathway

Anatomical studies have revealed a prominent role for feedback projections in the primate visual cortex. Theoretical models suggest that these projections support important brain functions such as attention, prediction, and learning. However, these models make different predictions about the relationship between feedback connectivity and neuronal stimulus selectivity. We have therefore performed simultaneous recordings in different regions of the primate dorsal visual pathway. Specifically, we recorded neural activity from the medial superior temporal (MST) area, and one of its main feedback targets, the middle temporal (MT) area. We estimated functional connectivity from correlations in the single-neuron spike trains and performed electrical microstimulation in MST to determine its causal influence on MT. Both methods revealed that inhibitory feedback occurred more commonly when the source and target neurons had very different stimulus preferences. At the same time, the strength of feedback suppression was greater for neurons with similar preferences. Excitatory feedback projections, in contrast, showed no consistent relationship with stimulus preferences. These results suggest that corticocortical feedback could play a role in shaping sensory responses according to behavioral or environmental context.NEW & NOTEWORTHY Here, we show that corticocortical feedback influences are often determined by the selectivity of the individual neurons. A common motif is the occurrence of inhibitory feedback among neurons with very different stimulus preferences. This results in strong suppression of responses in area MT when MST is electrically stimulated. Interestingly, this feedback shows a complex interaction with ongoing visual stimulation, being powerfully suppressive when visual inputs are strong, yet excitatory when visual inputs are weak.