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Updated: Jun 2, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Disrupted target binding with acryloyl group as potential Bcr-Abl/C-Src dual kinase inhibitor optimization strategies

Ching Lin1, Hsin-Yi Chiang1, Grace Shiahuy Chen2

  • 1National Taiwan University, School of Pharmacy, College of Medicine, Taipei 100 Taiwan.

Bioorganic & Medicinal Chemistry Letters
|January 15, 2025
PubMed

Keywords:
Acryloyl groupAnticancerKinase inhibitorQuinolone

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