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Updated: Jun 2, 2025

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Exploring TNFR1: from discovery to targeted therapy development.

Yingying Li1,2, Ruiwei Ye2, Haorui Dai2

  • 1School of Medicine, Shanghai Baoshan Luodian Hospital, Shanghai University, Shanghai, 201908, China.

Journal of Translational Medicine
|January 15, 2025
PubMed
Summary
This summary is machine-generated.

Tumor necrosis factor receptor 1 (TNFR1) plays a key role in inflammation and cell death. Targeting TNFR1 offers a promising therapeutic strategy for various diseases with potentially fewer side effects than TNF-α inhibitors.

Keywords:
ApoptosisInflammationTNFTNFR1Therapy

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Area of Science:

  • Immunology
  • Molecular Biology
  • Pharmacology

Background:

  • Tumor necrosis factor receptor 1 (TNFR1) is a crucial cell-surface receptor regulating inflammatory and cell death pathways.
  • TNFR1 signaling involves key pathways like nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK).
  • Dysregulation of TNFR1 is implicated in inflammatory disorders, infectious diseases, cancer, and metabolic syndromes.

Purpose of the Study:

  • To elucidate the therapeutic potential of TNFR1.
  • To enhance understanding of TNFR1's role in disease pathogenesis.
  • To explore selective TNFR1-targeted therapies as an alternative to TNF-α inhibition.

Main Methods:

  • Review of current clinical trials and preclinical studies on TNFR1.
  • Analysis of TNFR1 signaling pathways and their regulatory mechanisms.
  • Evaluation of emerging targeted therapies modulating TNFR1 activity.

Main Results:

  • TNFR1 signaling is central to various disease processes.
  • Selective TNFR1 inhibition presents a promising therapeutic avenue.
  • Targeting TNFR1 may offer improved efficacy and reduced side effects compared to TNF-α inhibitors.

Conclusions:

  • TNFR1 is a significant drug target with broad therapeutic potential.
  • Novel therapeutic strategies exploiting TNFR1 are emerging.
  • This review provides insights for future clinical applications of TNFR1-targeted therapies.