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Updated: Jun 27, 2026

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Food-Grade Microemulsion for High-Loading Octacosanol: Formulation Optimization, Characterization, and Biological

Jiayi Lin1, Shengang Yao1, Lanlan Li1

  • 1College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.

Foods (Basel, Switzerland)
|June 26, 2026
PubMed
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A novel food-grade microemulsion effectively delivers octacosanol (OCT) in beverages. This system overcomes poor solubility and low loading issues, enhancing OCT

Area of Science:

  • Food Science and Technology
  • Biomaterials Engineering
  • Nutraceutical Delivery Systems

Background:

  • Octacosanol (OCT) is a bioactive compound with health benefits but limited use in beverages due to poor water solubility.
  • Existing OCT delivery systems face challenges with low loading efficiency and high emulsifier concentrations.

Purpose of the Study:

  • To develop a food-grade microemulsion (ME) for enhanced octacosanol (OCT) delivery in functional beverages.
  • To achieve a high loading capacity for OCT in the microemulsion system.

Main Methods:

  • Formulation optimization using pseudo-ternary phase diagrams and analysis of particle size and polydispersity index (PDI).
  • Characterization of the optimized OCT-loaded microemulsion (OCT-ME), including stability and gastric protection.
Keywords:
biocompatibilityfunctional beveragein vitro digestionmicroemulsionoctacosanolstability

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Last Updated: Jun 27, 2026

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  • Evaluation of the biocompatibility of the developed OCT-ME system.

    • Main Results:

    • An optimal OCT-ME formulation was achieved with 1.0% OCT loading capacity.
    • The resulting OCT-ME exhibited a small particle size (10.37 nm), low PDI, and excellent stability.
    • The formulation demonstrated favorable gastric OCT protection and high biocompatibility (cell viability > 90%).

    Conclusions:

    • The developed food-grade OCT-ME effectively addresses limitations of previous delivery systems.
    • This microemulsion provides a promising solution for incorporating OCT into functional beverages.
    • The study offers theoretical support for efficient OCT solubilization and delivery.