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Impact of prolonged QTc interval on mortality risk with hypertrophic cardiomyopathy

Shun Hasegawa1, Satoshi Higuchi1,2, Yuichiro Minami1

  • 1Department of Cardiology Tokyo Women's Medical University Tokyo Japan.

Journal of Arrhythmia
|January 16, 2025
PubMed

Insights

In patients with hypertrophic cardiomyopathy (HCM), a prolonged corrected QT (QTc) interval is linked to an increased risk of HCM-related death. This finding highlights QTc prolongation as a significant predictor of adverse cardiac events in HCM patients.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Genetics

Background:

  • The association between corrected QT (QTc) interval and life-threatening cardiac events in hypertrophic cardiomyopathy (HCM) patients is not well-established.
  • This study aimed to clarify the relationship between QTc prolongation and HCM-related mortality.

Purpose of the Study:

  • To investigate if a prolonged QTc interval is an independent predictor of HCM-related death.
  • To determine the association between QTc prolongation and specific endpoints like sudden death or lethal arrhythmias in HCM.

Main Methods:

  • A cohort of 445 HCM patients was analyzed.
  • QTc interval was measured at baseline; prolongation was defined as >450 ms.
  • HCM-related death included sudden death, lethal arrhythmias, heart failure, and stroke.

Main Results:

  • 26.4% of patients had QTc prolongation at enrollment.
  • Over 8.1 years median follow-up, 15.1% experienced HCM-related death.
  • Prolonged QTc was independently associated with HCM-related death (aHR: 1.91) and sudden death/lethal arrhythmias (aHR: 2.01).

Conclusions:

  • QTc prolongation is a significant independent risk factor for HCM-related death.
  • This association extends to the combined endpoint of sudden death or potentially lethal arrhythmic events.
  • QTc interval assessment may aid risk stratification in hypertrophic cardiomyopathy patients.
Abstract

Keywords:
QTc intervalhypertrophic cardiomyopathyrisk stratificationsudden cardiac death

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