Can microbiota gut-brain axis reverse neurodegenerative disorders in human?

Area of Science:

• Microbiology
• Neuroscience
• Gastroenterology

Background:

• The gut microbiota plays a crucial role in health and disease.
• Dysbiosis, or reduced microbial diversity, is linked to neurodegenerative disorders (NDDs).
• The gut microbiota-brain axis is a key pathway for therapeutic interventions.

Purpose of the Study:

• To review the clinical significance of gut microbiota-based therapeutic strategies for NDDs.
• To identify research gaps and prospects in the gut microbiota-brain axis.
• To explore potential interventions for reversing NDDs.

Main Methods:

• Literature search of PubMed database using keywords 'gut microbiota' and 'Neurodegenerative disorders'.
• Inclusion of studies published in English within the last 5 years, including reviews, meta-analyses, and RCTs.
• Analysis focused on understanding the gut microbiota-brain axis, research gaps, and therapeutic prospects.

Main Results:

• Gut microbiota interventions show therapeutic potential for various diseases via the gut-brain axis.
• Non-pharmacological interventions appear more effective than pharmacological therapies for reversing NDDs.
• Early detection and preventive strategies are crucial for managing NDDs.

Conclusions:

• Gut-driven treatments offer significant promise for managing neurological diseases.
• Further research, including neuroimaging, is needed to establish clinical significance.
• A holistic approach is required to address structural and functional changes in the gut microbiota-brain axis.