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Updated: Jun 2, 2025
Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
Published on: September 13, 2014
Artificial liver support systems bridge severe immune-mediated hepatotoxicity to clinical recovery
Qiangfeng Wang1, Cheng Xiao1, Peipei Hu2
1Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Background:
The incidence of hepatic immune-related adverse events has increased with the wide use of immune checkpoint inhibitors (ICIs), some immune-mediated hepatotoxicity (IMH) cases are severe and lack of clinical recommendations.
Objective:
This study aimed to evaluate the efficacy of artificial liver support systems (ALSSs) in the treatment of IMH.
Methods:
This retrospective case series included six patients with grade 4 hepatotoxicity with high bilirubin induced by ICIs treated between 1 January 2019 and 31 December 2021. All patients received ALSS treatment.
Results:
After treatment and recovery, four of the six patients experienced improvement in hepatotoxicity, with total bilirubin (TBIL) levels reduced to ≤ grade 2, and two patients achieved complete recovery (TBIL grade = 0).
Conclusion:
ALSS serve as a therapeutic option for severe IMH.
