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PET-Based Risk Stratification in Primary Mediastinal B-Cell Lymphoma: A Comparative Analysis of Different
Luca Ceriani1,2, Lisa Milan3, Maria Cristina Pirosa4
1Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland; luca.ceriani@eoc.ch.
None:
Standardizing tumor measurement on 18F-FDG PET is crucial for the routine clinical use of powerful PET-derived lymphoma prognostic factors such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The recent proposal of an SUV of 4 as a new reference segmentation threshold for most aggressive lymphomas may homogenize volume-based metrics and facilitate their clinical application. Methods: This study compared MTV and TLG in primary mediastinal B-cell lymphoma (PMBCL) patients estimated using an SUV of 4 and the current threshold at 25% of SUVmax Baseline PET metrics were evaluated in 501 PMBCL patients from the IELSG37 trial. Results: Median MTV and TLG estimated with the 25% of SUVmax threshold were significantly lower than those obtained with the new reference threshold; however, an extremely high correlation was observed between the methods for both MTV (r = 0.95) and TLG (r = 0.99), resulting in superimposable prognostic power. Conclusion: These findings support the routine use of an SUV of 4 for volumetric measurements in PMBCL.
