Related Experiment Video
Updated: Jun 1, 2025
06:18
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
12.1K
An update on selective estrogen receptor modulator: repurposing and formulations.
Riya Patel1, Vanessa James2, Bhupendra Prajapati3,4
1School of Pharmacy, Indrashil University, Rajpur, Kadi, Gujarat, 382715, India.
Naunyn-Schmiedeberg'S Archives of Pharmacology
|January 17, 2025
Summary
Raloxifene hydrochloride (RLH), a SERM, shows promise for drug repurposing. This review details advanced formulation strategies, patents, and analytical methods to optimize RLH
Area of Science:
- Pharmacology
- Drug Discovery
- Medicinal Chemistry
Background:
- Raloxifene hydrochloride (RLH), a selective estrogen receptor modulator (SERM), is a key therapeutic agent for breast cancer and osteoporosis.
- Emerging clinical evidence suggests potential repurposing of RLH for diverse pathological conditions.
- Optimizing RLH's clinical utility necessitates a comprehensive understanding of its formulation, patent landscape, and analytical characterization.
Purpose of the Study:
- To provide a detailed review of raloxifene hydrochloride (RLH) drug repurposing.
- To explore the latest formulation strategies, patent advancements, and analytical methodologies for RLH.
- To identify current challenges and propose future research directions for RLH development.
Main Methods:
- Comprehensive literature analysis focusing on RLH repurposing and analytical techniques.
- Review of patent databases to identify key innovations and trends.
- Evaluation of formulation techniques, including advanced drug delivery systems.
Main Results:
- Sophisticated analytical techniques (spectroscopic, chromatographic, electrochemical) enhance RLH measurement and quality control.
- The patent landscape reveals significant innovation in RLH formulations, particularly for improved solubility and bioavailability.
- Advanced formulation techniques like transdermal patches and nanoparticulate systems offer improved therapeutic efficacy and overcome conventional limitations.
Conclusions:
- Raloxifene hydrochloride (RLH) exhibits significant potential for drug repurposing across various diseases.
- Innovations in formulation and analytical techniques are crucial for maximizing RLH's therapeutic benefits.
- Further research into novel drug delivery systems and expanded clinical applications of RLH is warranted.
Keywords:
Analytical techniquesDrug repurposingFormulation strategiesPatent landscapeRaloxifene hydrochloride (RLH)Selective estrogen receptor modulator (SERM)More Related Videos
Related Concept Videos
01:31Internal Receptors
69.3K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
69.3K
01:31Transducer Mechanism: Nuclear Receptors
1.3K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.3K
01:28Structure-Activity Relationships and Drug Design
493
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
493
01:25Dose-Response Relationship: Selectivity and Specificity
6.4K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
6.4K
01:29Drug-Receptor Interactions
4.8K
Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
4.8K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K