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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.6K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Related Experiment Video

Updated: Jun 1, 2025

A Chromatin Assay for Human Brain Tissue
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Epigenetic Control in Schizophrenia.

Claudio D'Addario1, Martina Di Bartolomeo2

  • 1Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy. claudio.daddario@ki.se.

Sub-Cellular Biochemistry
|January 17, 2025
PubMed
Summary

Schizophrenia, a major cause of disability, involves genetic and environmental factors. Analyzing epigenetic modulation offers insights into its development and potential new treatments for this complex psychiatric condition.

Keywords:
DNA MethylationEpigeneticHistone ModificationsSchizophreniamicroRNAs

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Last Updated: Jun 1, 2025

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Area of Science:

  • Psychiatric disorders
  • Neuroscience
  • Genetics and epigenetics

Background:

  • Schizophrenia is a severe psychiatric condition and a leading cause of global disability.
  • Its etiology involves a complex interplay of genetic and environmental risk factors.
  • Heritability is a well-established component in schizophrenia development.

Purpose of the Study:

  • To review clinical evidence on epigenetic modulation in schizophrenia.
  • To explore the relevance of epigenetics in understanding schizophrenia pathogenesis.
  • To assess the potential of epigenetic analysis for developing novel pharmacotherapies.

Main Methods:

  • Review of existing clinical evidence.
  • Analysis of epigenetic modulation in schizophrenia.
  • Exploration of genetic and environmental risk factors.

Main Results:

  • Epigenetic mechanisms are implicated in the complex pathogenesis of schizophrenia.
  • Clinical evidence supports the role of epigenetic modulation in schizophrenia.
  • Analysis of epigenetic changes may reveal new therapeutic targets.

Conclusions:

  • Epigenetic modulation is a crucial area for understanding schizophrenia.
  • Further research into epigenetics could lead to innovative pharmacotherapies.
  • Targeting epigenetic mechanisms may offer new treatment strategies for schizophrenia.