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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

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Targeting Oestrogen Receptor Signalling in Breast Cancer Therapy

Sacha J Howell1,2,3, Anthony Howell4,5,6

  • 1Division of Cancer Sciences, University of Manchester, Manchester, UK. sacha.howell@nhs.net.

Advances in Experimental Medicine and Biology
|January 17, 2025
PubMed

Insights

For over 130 years, endocrine therapies for breast cancer have evolved, targeting oestrogen receptor signalling. This review covers oestrogen deprivation and receptor blockade strategies, including their translation to early breast cancer prevention.

Area of Science:

  • Oncology
  • Endocrinology
  • Pharmacology

Background:

  • Breast cancer treatment has a 130-year history of targeting oestrogen receptor signalling.
  • Endocrine therapy remains a cornerstone in managing oestrogen receptor-positive breast cancer.

Purpose of the Study:

  • To summarise the development of key endocrine therapy pillars for breast cancer.
  • To discuss the translation of these therapies from advanced to early breast cancer settings.

Main Methods:

  • Review of oestrogen deprivation strategies (ovarian suppression, aromatase inhibition).
  • Review of oestrogen receptor blockade strategies (SERMs, SERDs, novel compounds).
  • Analysis of placebo-controlled breast cancer prevention studies for side effect profiles.

Main Results:

  • Key endocrine therapy pillars include oestrogen deprivation and receptor blockade.
  • Novel compounds are entering early phase development for breast cancer treatment.
  • Prevention studies provide accurate side effect profiles for these approaches.

Conclusions:

  • Endocrine therapy has significantly advanced over 130 years.
  • The translation to early breast cancer settings is crucial for prevention.
  • Understanding side effect profiles is vital for patient management and therapy selection.
Keywords:
Aromatase inhibitorsEndocrine therapyOestrogen receptorSelective estrogen receptor downregulatorTamoxifen

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