Transitioning to Green Discovery-Based Catalysis

Pressure is mounting to minimize the carbon footprint of chemical industry while increasing its sustainability. An argument is made that working from Green Chemistry principles during discovery-based catalysis results in effective chemistry and circumvents a need to "rediscover" chemical reactivity under sustainable conditions. Examples of comparative success in selected examples of hydrophosphination catalysis in various degrees of development are provided to support two main ideas: 1) Starting from more sustainable practices in chemical discovery is inertia in methodology that should be overcome, and 2) substantial challenges remain in catalysis for which sustainable solutions would positively impact other areas of chemistry. Examples of successes, even in the face of the challenges noted, are presented herein as indications that even as a starting point, sustainability can meet short- and long-term needs. These ideas indicate critical but simple strategies for fundamental research to be impactful in the sustainability of the chemical industry broadly.