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Easily Accessible and Solution-Stable Ni(0) Precatalysts for High-Throughput Experimentation
Gilian T Thomas1, Odhran D Cruise1, Daelin Peel-Smith1
1Department of Chemistry, University of Victoria, 3800 Finnerty Rd., Victoria, BC V8P 5 C2, Canada.
Abstract:
We report the synthesis, characterization, and catalytic applications of N,N'-diaryl diazabutadiene (DAB) Ni(0) complexes stabilized by alkene ligands. These complexes are soluble and stable in several organic solvents, making them ideal candidates for in situ catalyst formation during high-throughput experimentation (HTE). We used HTE to evaluate these Ni(0) precatalysts in a variety of Suzuki and C-N coupling reactions, and they were found to have equal or better performance than the still-standard Ni(0) source, Ni(COD)2.
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