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Molecular interactions between surface-active ionic liquids based on 2-hydroxyethylammonium laurate with gabapentin:
Mohammad Bagheri1, Fariba Ghaffari1, Hemayat Shekaari1
1Department of Physical Chemistry, University of Tabriz Tabriz Iran hemayatt@yahoo.com +984133340191 +984133393094.
RSC Advances
|January 17, 2025
Summary
Surface active ionic liquids (SAILs) aid gabapentin delivery by forming micelles. Their micellization behavior, influenced by temperature and gabapentin concentration, is key to improving bioavailability for this BCS class II drug.
Area of Science:
- Physical Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Surface active ionic liquids (SAILs) show promise for pharmaceutical applications.
- Gabapentin, an antiepileptic drug, exhibits low gastrointestinal permeability (BCS Class II).
- Understanding SAIL micellization is crucial for enhancing gabapentin bioavailability.
Purpose of the Study:
- To investigate the micellization and thermophysical properties of specific SAILs ([2-HEA][Lau], [BHEA][Lau], [THEA][Lau]) in aqueous gabapentin solutions.
- To determine the effect of temperature and gabapentin concentration on SAIL micelle formation.
- To elucidate the interactions between SAILs and gabapentin.
Main Methods:
- Utilized electrical conductivity and surface tension measurements to determine critical micelle concentration (CMC) and related properties.
- Employed Conductor-like Screening Model (COSMO) for analyzing component interactions.
- Calculated thermophysical parameters including interface surface pressure (Π) and minimum surface area per molecule (A_min).
Main Results:
- CMC values increased with temperature and decreased with increasing gabapentin concentration.
- SAILs demonstrated effective micelle formation in aqueous gabapentin solutions.
- Analysis of limiting molar conductivity (Λ₀) and association constant (K_A) provided insights into SAIL-gabapentin interactions.
Conclusions:
- SAILs are effective in forming micelles with gabapentin, offering a potential strategy for drug delivery.
- Temperature and gabapentin concentration significantly influence the micellization behavior of these SAILs.
- The study provides valuable data for the rational design of gabapentin delivery systems using SAILs.
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