Brain-inspired wiring economics for artificial neural networks

Wiring patterns of brain networks embody a trade-off between information transmission, geometric constraints, and metabolic cost, all of which must be balanced to meet functional needs. Geometry and wiring economy are crucial in the development of brains, but their impact on artificial neural networks (ANNs) remains little understood. Here, we adopt a wiring cost-controlled training framework that simultaneously optimizes wiring efficiency and task performance during structural evolution of sparse ANNs whose nodes are located at arbitrary but fixed positions. We show that wiring cost control improves performance across a wide range of tasks, ANN architectures and training methods, and can promote task-specific structural modules. An optimal wiring cost range provides both enhanced predictive performance and high values of topological properties, such as modularity and clustering, which are observed in real brain networks and known to improve robustness, interpretability, and performance of ANNs. In addition, ANNs trained using wiring cost can emulate the connection distance distribution observed in the brains of real organisms (such as Ciona intestinalis and Caenorhabditis elegans), especially when achieving high task performance, offering insights into biological organizing principles. Our results shed light on the relationship between topology and task specialization of ANNs trained within biophysical constraints, and their geometric resemblance to real neuronal-level brain maps.