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Failure of caffeine to affect substrate utilization during prolonged running.

D C Casal, A S Leon

    Medicine and Science in Sports and Exercise
    |February 1, 1985
    PubMed
    Summary

    Caffeine ingestion in well-trained marathoners elevated free fatty acids but did not alter substrate utilization during treadmill running. Perceived exertion decreased with both caffeinated and decaffeinated coffee compared to a control.

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    Area of Science:

    • Exercise Physiology
    • Nutritional Biochemistry

    Background:

    • Caffeine is a widely used ergogenic aid in endurance sports.
    • Its effects on substrate metabolism and performance in highly trained athletes require further investigation.

    Purpose of the Study:

    • To investigate the impact of caffeine on substrate utilization and perceived exertion during submaximal treadmill running in elite male marathoners.
    • To determine if caffeine alters key metabolic markers and physiological responses in trained endurance athletes.

    Main Methods:

    • Nine sub-3-hour male marathoners completed three 45-minute treadmill runs at 75% VO2max.
    • Participants consumed decaffeinated coffee or decaffeinated coffee with 400mg caffeine in a randomized, double-blind, crossover design.
    • Blood samples (free fatty acids, triglycerides, glucose, lactic acid) and respiratory measures (VO2, VCO2, R, VE) were analyzed.

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    Main Results:

    • Caffeine ingestion significantly increased plasma free fatty acids and lactic acid concentration prior to exercise.
    • No significant differences were observed in oxygen consumption (VO2), carbon dioxide production (VCO2), or respiratory exchange ratio (R) between conditions.
    • Perceived exertion was significantly lower in both caffeine and decaffeinated conditions compared to the control run.

    Conclusions:

    • While caffeine elevates pre-exercise free fatty acids, it does not appear to alter substrate utilization during submaximal running in well-trained marathoners.
    • Caffeine and decaffeinated coffee may reduce perceived exertion during prolonged exercise in this population.