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Related Experiment Video

Updated: Jun 1, 2025

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The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team-based approach to

Andrea L C Schneider1,2, Jennifer C Ginestra3,4, Meeta Prasad Kerlin3,4

  • 1Department of Neurology University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA.

Learning Health Systems
|January 17, 2025
PubMed
Summary

The CIRCE Project created a validated electronic health record (EHR) dataset from a large health system, improving data for clinical research and learning health systems. This cooperative model ensures data readiness for analysis.

Keywords:
electronic health record (EHR)learning health systemslearning healthcare systems

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Area of Science:

  • Health Informatics
  • Clinical Research Data Management
  • Learning Health Systems

Background:

  • Electronic health record (EHR) systems generate vast amounts of data valuable for research and hospital operations.
  • Challenges exist in making EHR data accessible, clean, standardized, and validated for research use.
  • A cooperative, systematic approach is needed to overcome these data challenges.

Purpose of the Study:

  • To describe the development of the Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) Project dataset.
  • To establish a model for cooperative, systematic extraction and validation of EHR data.
  • To create a de-identified, publicly available data resource for research and learning health system activities.

Main Methods:

  • A multi-disciplinary team developed the CIRCE Project dataset from six hospitals within the University of Pennsylvania Health System.
  • Analysts and clinical researchers iteratively reviewed SQL queries and output to validate data elements.
  • Data included patients aged ≥18 years with encounters since July 1, 2017, comprising raw, cleaned, and transformed layers.

Main Results:

  • The dataset captured 1,629,920 encounters from 740,035 patients between July 1, 2017, and December 31, 2023.
  • Most encounters were emergency department visits (59.3%), followed by inpatient admissions (23.7%).
  • The patient cohort included diverse demographics, with a median age of 46.9 years, 56.5% female, 36.8% non-White race, and 7.4% Hispanic/Latino ethnicity.

Conclusions:

  • The CIRCE Project demonstrates a novel cooperative research model for clinically validated EHR data.
  • This model facilitates collaboration and data sharing to support learning health system initiatives.
  • The project aims to ultimately provide a de-identified, publicly accessible EHR data resource.