Related Experiment Video
Updated: Jun 1, 2025
08:07
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
10.0K
Novel Allele HLA-B*52:130, Identified by Next-Generation Sequencing
Valery Cheranev1, Tatiana Jankevich1, Darya Smirnova2
1Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Medical University, Moscow, Russia.
HLA
|January 17, 2025
Summary
A novel Human Leukocyte Antigen (HLA)-B allele, HLA-B*52:130, has been identified. This new allele differs from HLA-B*52:01:01:01 by a single nucleotide change at codon 170.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The Human Leukocyte Antigen (HLA) system plays a critical role in immune response.
- HLA allele diversity is essential for understanding population genetics and disease susceptibility.
Purpose of the Study:
- To report the discovery and characterization of a new HLA-B allele.
Main Methods:
- Nucleotide sequencing of the HLA-B gene.
- Comparison of novel sequences against existing HLA allele databases.
Main Results:
- A new allele, designated HLA-B*52:130, was identified.
- This allele differs from the known HLA-B*52:01:01:01 allele by a single nucleotide substitution at codon 170, resulting in a nonsynonymous change.
Conclusions:
- The identification of HLA-B*52:130 expands the known HLA-B allele repertoire.
- This finding contributes to the ongoing cataloging of human genetic variation within the HLA system.
