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Updated: Jun 1, 2025

Hydrolysis of a Ni-Schiff-Base Complex Using Conditions Suitable for Retention of Acid-labile Protecting Groups
Published on: April 6, 2017
Synthesis of Unprotected Racemic Tryptophan Derivatives Using Gramine via Nickel(II) Complex
Qiangqiang Chen1,2, Yazhou Li2,3, Zhekai Xiao3,4
1School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
Abstract:
A chemical method for the preparation of nonprotected tryptophan via nickel(II) complexes under simple operating conditions was established. The carefully designed nickel(II) glycinates are inexpensive and can be quantitatively recovered releasing the target tryptophans in high yield. The method has a wide range of synthesis generality, allowing the preparation of various substituted tryptophans. Furthermore, the scalability of this method bodes well for its synthetic use as a general approach to biologically interesting tailor-made tryptophans and related compounds.
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