Related Experiment Video
Updated: Jun 19, 2026
05:56
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
Low-Level Red Light for the Progression Myopia in Children: A Meta-Analysis
Xian Yang1, Lin Yao2, Gang Sun3
1Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Seminars in Ophthalmology
|January 18, 2025
Summary
Low-level red light (LRL) therapy effectively controls myopia progression in children. This treatment also reduces axial length elongation and subfoveal choroid thickness changes in both myopia and premyopia.
Area of Science:
- Ophthalmology
- Pediatrics
- Biomedical Optics
Background:
- Myopia is a growing global health concern in children.
- Early intervention is crucial for myopia control.
- Low-level red light (LRL) therapy is an emerging treatment modality.
Purpose of the Study:
- To systematically analyze the efficacy of LRL therapy for myopia control and prevention in children.
- To evaluate LRL's impact on refractive error progression and axial length.
- To assess LRL's effect on subfoveal choroid thickness.
Main Methods:
- Systematic meta-analysis of randomized controlled trials (RCTs).
- Searched PubMed, EMBASE, and Cochrane Library databases.
- Included RCTs involving participants under 18 years old.
Main Results:
- LRL therapy significantly reduced spherical equivalent refractive error progression in myopia children (MD, 0.49; p < .00001).
- LRL treatment led to less axial length change (MD, -0.24) and subfoveal choroid thickness increase (MD, 28.16) in myopia and premyopia.
- Statistical significance was achieved for all primary outcomes (p < .00001).
Conclusions:
- LRL therapy is effective in delaying refractive error progression in children with myopia.
- LRL therapy can reduce axial length elongation and subfoveal choroid thickness changes.
- LRL therapy shows promise for both myopia control and prevention in pediatric populations.
Related Concept Videos
01:16Focusing of Light in the Eye
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...