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Protocol for reconstructing ancestral genomes from present-day samples by applying local ancestry inference.

Xiaoxi Zhang1, Baonan Wang2, Jia Wen2

  • 1Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

STAR Protocols
|January 18, 2025
PubMed
Summary

Reconstructing ancestral genomes from present-day DNA is now possible. This protocol aids in inferring demographic history and identifying local adaptations by analyzing genetic ancestry.

Keywords:
BioinformaticsEvolutionary biologyGeneticsGenomics

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