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Updated: Jun 1, 2025

Sample Drift Correction Following 4D Confocal Time-lapse Imaging
Published on: April 12, 2014
Log subtracted inversion recovery
Mark Bydder1, Daniel M Cornfeld2, Tracy R Melzer3
1Mātai Medical Research Institute, Tairāwhiti, Gisborne, New Zealand.
Abstract:
Magnetic resonance imaging (MRI) techniques have recently been developed for obtaining high T1 contrast images using inversion recovery (IR) images at two inversion times (TIs) rather than a single TI. They use simple mathematical operations - multiplication, addition, subtraction, division - to create images not attainable by conventional IR. The present study describes a novel two-point IR technique formed by the subtraction of log images. Results show it has a near-linear response to T1 between the nullpoints that peaks sharply at the nullpoints. This produces a bright isoT1 contour at interfaces between tissues where partial volume mixing generates specific T1s. This can provide anatomical information in areas where the signal is not well-differentiated on conventional images.
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