Related Experiment Video

Updated: May 1, 2026

Growth and Characterization of Irradiated Organoids from Mammary Glands
09:49

Growth and Characterization of Irradiated Organoids from Mammary Glands

Published on: May 3, 2019

8.0K

Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation

Merian E Kuipers1, Dennis K Ninaber2, Krista C J van Doorn-Wink3

  • 1Department of Pulmonology, Leiden University Medical Centre (LUMC), Albinusdreef 2, C2-R-062, 2333 ZA, Leiden, The Netherlands. m.e.kuipers1@lumc.nl.

Respiratory Research
|January 18, 2025
PubMed
Summary

Ionizing radiation (IR) impairs lung epithelial progenitor cell function, reducing organoid formation for at least 7 days. This effect occurs without significant cytotoxicity, inflammation, or epithelial-mesenchymal transition, highlighting a sensitive method for studying radiation-induced lung injury (RILI).

More Related Videos

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

8.0K
Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures08:42

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

2.7K

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
40