Oral barriers to food-derived active peptides and nano-delivery strategies

Food-derived bioactive peptides are a class of peptides from natural protein. It may have biological effects on the human body and play a significant role in protecting human physiological health and regulating physiological metabolism, such as lowering blood pressure, lowering cholesterol, antioxidant, antibacterial, regulating immune activity, and so on. However, most of the natural food-derived functional peptides need to overcome a variety of barriers in the body to enter the blood circulation system and target to specific tissues to generate physiological activity. During this process, the bioavailability of the functional peptides will be reduced. The nano-delivery system can offer the feasibility to overcome these obstacles and improve the stability and bioavailability of food-derived active peptides by nanoencapsulation. This work summarizes the application of food-derived bioactive peptides and the obstacles during the delivery pathway in vivo. Moreover, the different nano-delivery systems used for bioactive peptides and their application were summarized, which could provide ideas for oral delivery of food-derived bioactive peptides.