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Updated: Jun 1, 2025

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Computational frameworks transform antagonism to synergy in optimizing combination therapies
Jinghong Chen1,2, Anqi Lin1, Aimin Jiang3
1Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Abstract:
While drug combinations are increasingly important in disease treatment, predicting their therapeutic interactions remains challenging. This review systematically analyzes computational methods for predicting drug combination effects through multi-omics data integration. We comprehensively assess key algorithms including DrugComboRanker and AuDNNsynergy, and evaluate integration approaches encompassing kernel regression and graph networks. The review elucidates artificial intelligence applications in predicting drug synergistic and antagonistic effects.
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