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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Author Spotlight: In Vitro Hydrogel Model for Glioblastoma Microenvironment Study
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Tumor microenvironment as a target for developing anticancer hydrogels.

Suman Khurana1,2, Shrestha Sharma1, Parveen Kumar Goyal2

  • 1Amity Institute of Pharmacy, Amity University Haryana, Gurugram, India.

Drug Development and Industrial Pharmacy
|January 20, 2025
PubMed
Summary
This summary is machine-generated.

Smart hydrogels targeting the tumor microenvironment (TME) offer a novel approach to cancer treatment. These stimuli-responsive formulations enhance drug efficacy and reduce side effects by responding to TME-specific features.

Keywords:
TME-targetTumor microenvironmentanticancerhydrogelsstimuli-responsive polymers

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Cancer cells are protected by the complex tumor microenvironment (TME).
  • The TME comprises diverse cells like immune cells, endothelial cells, and fibroblasts.
  • Targeting TME features is a novel strategy for anticancer drug development.

Purpose of the Study:

  • To review characteristic features of the TME as targets for smart anticancer hydrogels.
  • To explore stimuli-responsive hydrogels for targeted cancer therapy.

Main Methods:

  • Literature review using public domain data from online resources (Google Scholar, PubMed, Scopus, etc.).

Main Results:

  • Smart hydrogels sensitive to TME features (low pH, glutathione, enzymes) are promising anticancer formulations.
  • These hydrogels improve chemotherapy efficacy and reduce side effects.

Conclusions:

  • Stimuli-responsive hydrogels are gaining attention for targeted drug delivery to the TME.
  • Hydrogels offer biocompatibility, stimuli-responsiveness, and improved drug delivery for cancer treatment.