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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Causal Relationship Between Emotional Disorders and Thyroid Disorders: A Bidirectional Two-Sample Mendelian

Jiaying Fan1, Kai Zhou1, Cuiwen Yu1

  • 1Department of Endocrinology, Ningbo Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Ningbo, Zhejiang, China.

Brain and Behavior
|January 20, 2025
PubMed
Summary
This summary is machine-generated.

This study explored the genetic links between emotional and thyroid disorders. Findings suggest a complex, bidirectional relationship, indicating thyroid issues may influence emotional health and vice versa.

Keywords:
Mendelian randomization studycausal relationshipemotional disordersthyroid disorders

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Area of Science:

  • Endocrinology
  • Psychiatry
  • Genetics

Background:

  • Observational studies suggest links between emotional and thyroid disorders but lack causal evidence.
  • Multifactorial etiology complicates understanding the interplay between these conditions.

Purpose of the Study:

  • To investigate the genetic causal associations between emotional disorders and thyroid disorders using a bidirectional Mendelian randomization (MR) approach.

Main Methods:

  • Employed inverse-variance weighted (IVW), weighted median, weighted mode, and MR Egger regression.
  • Conducted sensitivity analyses using MR-Egger, MR Pleiotropy Residual Sum and Outlier (MR-PRESSO), Cochran's Q, and leave-one-out methods.

Main Results:

  • Negative causal relationships were observed between emotional disorders and hypothyroidism, toxic single thyroid nodules, and hyperthyroidism.
  • Positive causal links were found between anxiety disorders and hypothyroidism, and between hypothyroidism/autoimmune thyroiditis and depression.
  • Reverse MR analysis indicated a negative causal relationship between hyperthyroidism and bipolar disorder.

Conclusions:

  • This bidirectional MR study suggests a complex, bidirectional causal relationship between emotional and thyroid disorders.
  • Thyroid dysfunction may play a role in the development of certain emotional disorders, and emotional disorders may influence thyroid health.