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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

54
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
54

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Related Experiment Video

Updated: May 1, 2026

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts
07:58

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[Neurocytoprotection advances in reperfusion therapy].

I A Shchukin1,2, I A Koltsov1,2, M S Fidler1

  • 1Pirogov Russian National Research Medical University (Pirogov University), Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|January 20, 2025
PubMed
Summary

Acute stroke, primarily ischemic stroke, causes significant death and disability. Combining reperfusion therapy with neurocytoprotection may improve treatment efficacy and safety by preserving brain tissue.

Keywords:
cytoprotectionintravenous thrombolysisischemic strokemechanical thrombectomyneurocytoprotectionneuroprotectionreperfusion injuryreperfusion therapy

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Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroscience

Background:

  • Acute stroke is a leading global cause of death and disability.
  • Ischemic stroke (IS) is the most common type, involving complex brain tissue damage.
  • Reperfusion therapy (RT) is a key treatment for acute IS, with proven efficacy and safety.

Purpose of the Study:

  • To review current trials investigating neurocytoprotection combined with reperfusion therapy in IS patients.
  • To explore the potential of combining RT with neurocytoprotection to improve treatment outcomes.
  • To analyze strategies for preserving brain tissue in the ischemic penumbra.

Main Methods:

  • Systematic review of randomized clinical trials.
  • Analysis of neuroimaging techniques (CT-perfusion, MRI) for RT selection.
  • Evaluation of neurocytoprotective strategies in conjunction with RT.

Main Results:

  • Novel neuroimaging has expanded RT eligibility in IS patients.
  • Combining RT with neurocytoprotection is a promising strategy.
  • Preserving ischemic penumbra tissue is a key therapeutic goal.

Conclusions:

  • Neurocytoprotection combined with RT holds potential to enhance treatment efficacy and safety for IS.
  • Further research into combined therapies is warranted to optimize stroke management.
  • Expanding RT criteria through advanced imaging and protective strategies is crucial.