Recent progress in C-S bond formation via electron donor-acceptor photoactivation
Sichang Wang1, Liting Wang1, Jin Cui2
1College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China. kcy@xsyu.edu.cn.
Organic & Biomolecular Chemistry
|January 20, 2025
Summary
Electron donor-acceptor (EDA) complex photoactivation enables efficient C-S bond formation. This review covers recent advances in EDA-promoted sulfonylation and thiolation using various sulfur sources for greener synthesis.
Area of Science:
- Organic Chemistry
- Photochemistry
- Synthetic Chemistry
Background:
- C-S bond formation is crucial in synthesizing sulfur-containing compounds.
- Traditional methods often require harsh conditions or toxic reagents.
- Electron donor-acceptor (EDA) complex photoactivation offers a milder alternative.
Purpose of the Study:
- To review recent advancements in C-S bond formation using EDA complex photoactivation.
- To highlight the application of various sulfur-containing substrates in these reactions.
- To showcase environmentally friendly synthetic pathways.
Main Methods:
- Utilizing electron donor-acceptor (EDA) complexes.
- Employing visible light irradiation for photoactivation.
- Investigating single-electron transfer (SET) mechanisms.
Main Results:
- Successful C-S bond formation under mild conditions.
- Demonstrated utility of diverse sulfur sources: diacetoxybenzenesulfonyl (DABSO), sulfonic acids, sodium sulfinates, sulfonyl chlorides, and thiophenols.
- Development of novel sulfonylation and thiolation reactions.
Conclusions:
- EDA complex photoactivation is a powerful strategy for C-S bond formation.
- These methods provide sustainable and efficient routes to sulfur-containing molecules.
- The reviewed reactions represent significant progress since 2017.
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