Related Experiment Video

Updated: May 7, 2026

Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area
09:08

Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area

Published on: February 2, 2017

16.2K

Chinese stroke association guidelines on reperfusion therapy for acute ischaemic stroke 2024

Yunyun Xiong1,2, Shuya Li1,2, Chunjuan Wang1,2

  • 1Department of Neurology, Beijing Tiantan Hospital, Beijing, China.

Stroke and Vascular Neurology
|January 20, 2025
PubMed

Insights

This guideline updates recommendations for reperfusion therapy in acute ischaemic stroke, including thrombolysis and thrombectomy. It provides the latest evidence to help clinicians optimize patient selection and treatment decisions for better stroke outcomes.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Emergency Medicine

Background:

  • Stroke is a leading global health issue, with China facing a high burden of ischaemic stroke.
  • Reperfusion therapies, including thrombolysis and thrombectomy, significantly improve outcomes for acute ischaemic stroke.
  • Recent trials have expanded the use and efficacy of thrombolytic agents and thrombectomy procedures.

Purpose of the Study:

  • To provide updated, evidence-based guidelines for reperfusion therapy in acute ischaemic stroke.
  • To incorporate the latest clinical trial data on thrombolytic agents and mechanical thrombectomy.
  • To assist clinicians in optimizing patient selection and treatment strategies.

Main Methods:

  • Development of guidelines by the Chinese Stroke Association (CSA) writing group.
  • Comprehensive literature search of MEDLINE (PubMed) up to September 30, 2024.
  • Expert consensus and evidence grading using CSA's Guideline Development Manual.

Main Results:

  • The guideline details patient selection criteria for thrombolysis and thrombectomy.
  • It summarizes current evidence on various thrombolytic drug options for informed decision-making.
  • Includes practical flow charts for rapid implementation of intravenous thrombolysis and mechanical thrombectomy.

Conclusions:

  • The guideline represents an update on advancements in acute ischaemic stroke reperfusion therapy.
  • Future research is expected to focus on novel thrombolytic agents and expanded treatment indications.
  • These updated recommendations aim to improve clinical practice and patient outcomes in China and beyond.
Abstract

Keywords:
Ischaemic StrokeThrombectomyThrombolysis

More Related Videos

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

17.1K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.0K

Related Concept Videos

Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
528
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
57
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
74