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Updated: Jun 12, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

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Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment.

Shristy Chaudhary¹, Abhilash Rana¹, Seema Bhatnagar¹

¹Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

Mini Reviews in Medicinal Chemistry

|January 21, 2025

Summary

This summary is machine-generated.

Cancer cells reprogram metabolism for growth. This review explores targeting these metabolic changes using repurposed drugs for effective cancer therapy.

Keywords:

Drug repurposing cancer cancer metabolism cancer treatment cell death.metabolic reprogramming

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Area of Science:

Oncology
Metabolic pathways
Cancer biology

Background:

Metabolic reprogramming is a key characteristic of cancer, driving tumor growth.
Oncogenic pathways converge to alter glucose, lipid, and amino acid metabolism in tumor cells.
Targeting cancer cell metabolism offers a promising therapeutic strategy.

Purpose of the Study:

To review aberrant metabolic pathways in cancer.
To explore strategies for targeting metabolic reprogramming.
To highlight the potential of drug repurposing in cancer therapy.

Main Methods:

Review of scientific literature on cancer metabolism.
Analysis of oncogenic signaling pathways affecting metabolism.
Identification of drug repurposing opportunities for metabolic targets.

Main Results:

Metabolic aberrations are crucial for tumor development.
Targeting metabolic nodes can inhibit cancer progression.
Drug repurposing presents a viable strategy for developing new anticancer agents.

Conclusions:

Understanding cancer-specific metabolic reprogramming is vital.
Targeting metabolic pathways with repurposed drugs offers a promising therapeutic avenue.
Drug repurposing can accelerate the development of effective, affordable cancer treatments.