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Updated: Jun 1, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Arthritis: Knee and Hip Arthroplasty
Fern E Kopp-Mulberg, Heli Naik1
1Family medicine residency program at Rutgers University/Robert Wood Johnson University Hospital Somerset, Somerville, NJ.
Abstract:
Approximately 800,000 total knee arthroplasties and 450,000 total hip arthroplasties are performed annually in the United States. These procedures provide significant pain relief and restore function in patients with advanced osteoarthritis, rheumatoid arthritis, and other degenerative joint conditions. Patient evaluation before surgery includes a history, physical examination, laboratory tests, and imaging. After surgery, the rapid recovery protocol typically is used. This involves early mobilization of the replaced joint with ambulation as soon as 4 to 8 hours after surgery. Postoperative analgesia may include nerve block local infiltration anesthesia within the first 24 hours, along with opioids, cyclooxygenase-2 selective inhibitors, and acetaminophen. Periprosthetic joint infections are the primary reason for revision arthroplasty; they occur in 1% to 2% of patients. Risk factors include obesity, diabetes, poor nutritional status, and smoking. Routine use of anticoagulants has decreased the postoperative rate of venous thromboembolism. Rehabilitation includes stretching, muscle strengthening, and exercises to increase range of motion and improve gait, balance, and neuromuscular function. This can be performed in an in- or outpatient setting. In the postoperative period, most patients can resume a majority of daily activities within 6 weeks. After 3 months, most patients are functioning at 90% capacity, with full recovery by 1 year.
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