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Updated: Jun 1, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Arthritis: Knee and Hip Arthroplasty
Fern E Kopp-Mulberg, Heli Naik1
1Family medicine residency program at Rutgers University/Robert Wood Johnson University Hospital Somerset, Somerville, NJ.
Total knee and hip arthroplasty offer pain relief for joint conditions. Rapid recovery protocols and rehabilitation help patients regain function within a year.
Area of Science:
- Orthopedic Surgery
- Rehabilitation Medicine
Background:
- Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are common procedures for degenerative joint diseases.
- These surgeries significantly improve pain and function for millions annually in the US.
Purpose of the Study:
- To outline the standard pre-operative evaluation, surgical protocols, and post-operative management for TKA and THA.
- To discuss common complications, risk factors, and rehabilitation strategies to optimize patient outcomes.
Main Methods:
- Review of pre-operative assessments including history, physical exam, labs, and imaging.
- Description of rapid recovery protocols involving early mobilization (4-8 hours post-op).
- Overview of multimodal analgesia (nerve blocks, opioids, NSAIDs, acetaminophen) and VTE prophylaxis.
Main Results:
- Periprosthetic joint infection (1-2%) is a key risk for revision, influenced by obesity, diabetes, and smoking.
- Early mobilization and multimodal analgesia facilitate faster recovery and reduced VTE rates.
- Rehabilitation focuses on range of motion, strength, gait, and balance, with most patients resuming activities in 6 weeks.
Conclusions:
- TKA and THA are effective for joint pain and dysfunction.
- Rapid recovery protocols, comprehensive pain management, and dedicated rehabilitation are crucial for optimal patient function.
- Patients typically achieve 90% capacity by 3 months and full recovery within 1 year post-surgery.
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