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Published on: August 15, 2019
MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays
Alan F Rubin1,2, Jeremy Stone3, Aisha Haley Bianchi4
1Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia. alan.rubin@wehi.edu.au.
Abstract:
Multiplexed assays of variant effect (MAVEs) are a critical tool for researchers and clinicians to understand genetic variants. Here we describe the 2024 update to MaveDB ( https://www.mavedb.org/ ) with four key improvements to the MAVE community's database of record: more available data including over 7 million variant effect measurements, an improved data model supporting assays such as saturation genome editing, new built-in exploration and visualization tools, and powerful APIs for data federation and streamlined submission and access. Together these changes support MaveDB's role as a hub for the analysis and dissemination of MAVEs now and into the future.
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