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Cross-Section of Hypertensive Molecular Signaling Pathways: Understanding Pathogenesis and Identifying Improved Drug
Jeyanthi Sankar1, Kannan Rajendran2, Ling Shing Wong3
1Pharmacogenomics and CADD Lab, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
Hypertension, a chronic condition, is linked to cardiovascular and renal diseases. Understanding its complex genetic and non-genetic pathways, including the Renin-Angiotensin-Aldosterone System (RAAS), is key to developing safer, effective blood pressure treatments.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Pharmacology
Background:
- Hypertension is a chronic condition significantly contributing to cardiovascular and renal diseases.
- Both genetic and non-genetic factors influence hypertension development.
- The Renin-Angiotensin-Aldosterone System (RAAS) is a primary genetic target for current antihypertensive strategies.
Purpose of the Study:
- To review signaling pathways involved in hypertension pathogenesis.
- To elucidate the cross-talks among these pathways.
- To contribute to a better understanding of hypertension etiology and identify novel therapeutic targets.
Main Methods:
- Literature review of signaling pathways in hypertension.
- Analysis of RAAS-dependent and RAAS-independent pathways.
- Examination of interactions and cross-talks between different physiological systems.
Main Results:
- Classical antihypertensive drugs primarily target RAAS signaling.
- While effective in blood pressure control, these drugs can cause severe side effects.
- Novel therapeutic targets may arise from RAAS-dependent, RAAS-independent, or cross-talk pathways.
Conclusions:
- A comprehensive understanding of hypertension's physiopathological mechanisms is crucial.
- Investigating interactions between systems aids in identifying better drug targets.
- Emergence of novel therapeutics requires exploring diverse signaling pathways beyond RAAS.
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